PERBANDINGAN AKTIVITAS ANTI-HIPERURISEMIA EKSTRAK ETANOL SELEDRI (APIUM GRAVEOLENS L.) DAN DAUN SALAM (SYZYGIUM POLYANTHUM) PADA MENCIT YANG DIINDUKSI KAFEIN
Keywords:
uric acid, apigenin, flavonoidsAbstract
Celery plants (Apium Graveolens L) and bay leaves (Syzygium polyanthum) have been used as alternative medicine to treat Hyperuricemia. This study aimed to determine the effectiveness of administration of extracts from celery plants and bay leafs to decrease uric acid levels in blood. This research used a post-test control group only design. A total of 24 male mice (randomly divided into 4 groups; P0, P1, P2 and P3). P0 was the control group (induced with caffeine at a dose of 0.5 mg/kgBW). P1 was induced with caffeine 0.5 mg/kgBW+celery extract 35 mg/kgBW, P2 was induced by caffeine 0.5 mg/kgBW+bay leaf extract 35 mg/kgBW and P3 was induced by caffeine + a combination of celery plant extract and bay leaves 35mg/kgBW. Uric acid levels were measured using an easy touch GCU meter device. The results showed that average of uric acid level for P0, P1, P2 and P4 were 7.1mg/dl; 4.9 mg/dl; 4 mg/dl; and 5.2 mg/dl, respectively. The most significant antihyperuricemia activity was demonstrated by administering 35 mg/kgBW of bay leaf extract. The One Way ANOVA analysis described that the administration of extract ethanol generated significant effects (p-value <0.05). Based on post hoc LSD analysis, it was found that the administration of ethanol extract from bay leaves showed significant differences compared to combination (celery + bay leaves) in lowering uric acid levels. Therefore, it was concluded extract from celery and bay leaves can be used to lower the level of uric acid
References
Astuti, R. P. (2018). Uji efek kombinasi ekstrak air daun salam (Syzygium polyanthum (wight.) walp) dan ekstrak etanol herba seledri (Apium graviolens l.) terhadap penurunan kadar asam urat tikus jantan galur wistar yang diinduksi potassium oxonate. Skripsi. Sekolah Tinggi Ilmu Kesehatan Nasional Surakarta. Surakarta
Darussalam, M., & Kartika Rukmi, D. (2019). Peran Air Rebusan Daun Salam (Syzgium Polyanthum) dalam Menurunkan Kadar Asam Urat. Media Ilmu Kesehatan, 5(2), 83–91.
Emad, Y., Dalbeth, N., Weinman, J., Chalder, T., & Petrie, K. J. (2022). Why do patients with gout not take Allopurinol, Journal of Rheumatology, 49(6), 622–626.
Kholieqoh, A. H., Anam, K., & Kusrini, D. (2022). Isolation and antioxidant activity of flavonoid compound in ethanolic extract of celery leaves (Apium graveolens L.). Jurnal Kimia Sains Dan Aplikasi, 25(12), 450–455.
Mahmudah, R., Yusuf, M. I., & Nur, W. O. I. (2023). Uji efektivitas antihiperurisemia kombinasi ekstrak etanol daun kelor (Moringa aloeifere L.) dan Daun Sukun (Artocarpus altilis) pada Tikus Jantan (Rattus norvegicus). Jurnal Mandala Pharmacon Indonesia, 9(2), 532–542.
Mehmood, A., Zhao, L., Wang, C., Nadeem, M., Raza, A., Ali, N., & Shah, A. A. (2019). Management of hyperuricemia through dietary polyphenols as a natural medicament: A comprehensive review. Critical Reviews in Food Science and Nutrition, 59(9), 1433–1455.
Pertiwi, N. I. (2016). Perbedaan Kadar Asam Urat Mengunakan Alat Spektrometri dengan Alat Point Of Care Testing (POCT).Skripsi. Universitas Muhammadyah Semarang. Semarang
Pratama, B. P. et al. (2021). Different leaf maturities and withering durations affect the antioxidant potential and aroma compound of Indonesian bay leaf [Syzygium polyanthum (Wight) Walp.]. International Food Research Journal, 28(6), 1196.
Pratiwi. (2021). Formulasi dan uji evaluasi sediaan sirup ekstrak etanol daun salam (Syzygium polyanthum) formulation and evaluation test syrup for ethanol extract of bay leaf (Syzygium polyanthum). IJMS-Indonesian Journal On Medical Science, 8(2), 166–171.
Wulandari,S., Lasanuddin, H. V., Nur, U. I., Biahimo, & Sudirman. A.N. (2023). Pemberian rebusan daun salam pada lansia dengan asam urat di griya lansia jannati Kota Gorontalo. Jurnal Ventilator, 1(2), 65–82.
Wahyuni, A. (2016). Jurnal Ipteks Terapan. Senam Kaki Diabetik Efektif Meningkatkan Ankle Brachial Index Pasien Diabetes Melitus Tipe 2, 4(Jurnal Ipteks Terapan), 252–261.
Wahyuni, N., & Awaludin, A. A. (2023). Pengaruh Pemberian Seduhan Herba Seledri (Apium graveolens L.) terhadap Penurunan Kadar Asam Urat Dalam Darah pada Pasien Lansia. Jurnal Medika Farmaka, 1(1), 15–27.
Yunarto, N. et al. (2022). Antioxidant Activity and Inhibition of HMG CoA Reductase Enzyme by Bay Leaf (Syzygium polyanthum Wight) Extract as a Treatment for Hyperlipidemia. Tropical Journal of Natural Product Research, 6(11), 1798.
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